β-Globin Gene Sequencing of Hemoglobin Austin Revises the Historically Reported Electrophoretic Migration Pattern

Electrophoretic Components of the Hemoglobin

Erythrocyte membranes prepared by repeated washings with water have been shown by Anderson and Turner (1) to contain relatively constant amounts of hemoglobin. The hemoglobin of lyophilized erythrocyte membranes represented about 3 per cent of the total erythrocyte hemoglobin and between 49 and 57 per cent of dry weight of the membranes (1). No differences between the membrane hemoglobin and th...

A study of the Electrophoretic Pattern of the serum Proteins

β-Globin Gene Regulation and Nuclear Organisation

Co-inheritance of α-and β-thalassemia: challenges in prenatal diagnosis of thalassemia

Background: The double heterozygous state of α/β thalassemia may alter the hematological indices and modify the phonotype. In addion, definite characterizaon of co-inheritance of α- and β-thalassemia heterozygous carriers may change the process of genec counseling. Materials and Methods: An Iranian couple with low hematological indices was analyzed for α-globin gene deleons using mulpl...

The First Report of a 290-bp Deletion in β-Globin Gene in the South of Iran

Background: β-thalassemia is one of the most widespread disease in the world, including Iran. In this study, we reported, for the first time, A 290-bp β-globin gene deletion in the south of Iran. Methods: Four individuals from three unrelated families with Arabic ethnic background were studied in Khuzestan Province. Red blood cell indices and hemoglobin analysis were carried out accor...